Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment.

Nistala, Kiran; Adams, Stuart; Cambrook, Helen; Ursu, Simona; Olivito, Biagio; de Jager, Wilco; G Evans, Jamie; Cimaz, Rolando; Bajaj-Elliott, Mona; R Wedderburn, Lucy

doi:10.1073/pnas.1003852107

Public

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment.

Published in Proceedings of the National Academy of Sciences of the United States of America • Aug 17, 2010

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Authors:

Kiran Nistala

,

Stuart Adams

,

Helen Cambrook

Abstract

In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of inflammation. In human arthritis the majority of IL-17-secreting cells within the joint express a cytokine phenotype intermediate between Th17 and Th1. Here we show that Th17/1 cells from the joints of childr...

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