Copper‐Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl‐Substituted Aromatic N‐Heterocycles

A direct synthesis of carbaldehydes through intramolecular dehydrogenative aminooxygenation has been developed. The process uses a catalytic amount of copper(II) in DMF or DMA under oxygen and does not require additional oxidants (see scheme). Mechanistic studies suggest that the carbonyl oxygen ato... View More