Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

H. Kehrl, John; M. Wakefield, Lalage; B. Roberts, Anita; B. Jakowlew, Sonia; Alvarez-Mon, M; Derynck, Rik; B. Sporn, Michael; S. Fauci, Anthony

doi:10.1084/jem.163.5.1037

Public

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Published in The Journal of Experimental Medicine • May 1, 1986

Authors:

John H. Kehrl

Lalage M. Wakefield

Anita B. Roberts

Abstract

This study examines the potential role of transforming growth factor beta (TGF-beta) in the regulation of human T lymphocyte proliferation, and proposes that TGF-beta is an important autoregulatory lymphokine that limits T lymphocyte clonal expansion, and that TGF-beta production by T lymphocytes is...

Subject

Lymphokine

Transforming growth factor beta

Biology

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