Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Hidalgo, Manuel; Amant, Frédéric; V. Biankin, Andrew; Budínská, Eva; T. Byrne, Annette; Caldas, Carlos; B. Clarke, Robert; de Jong, Steven; Jonkers, Jos; M. Mælandsmo, Gunhild; Roman‐Roman, Sergio; Seoane, Joan; Trusolino, Livio; Villanueva, Alberto

doi:10.1158/2159-8290.cd-14-0001

Public

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Published in Cancer Discovery • Jul 16, 2014

Authors:

Manuel Hidalgo

Frédéric Amant

Andrew V. Biankin

Abstract

UNLABELLED: Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passage...

Subject

Personalized medicine

Precision medicine

Translational research

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