Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Hidalgo, Manuel; Amant, Frederic; V. Biankin, Andrew; Budinská, Eva; T. Byrne, Annette; Caldas, Carlos; B. Clarke, Robert; de Jong, Steven; Jonkers, Jos; Mari Mælandsmo, Gunhild; Roman-Roman, Sergio; Seoane, Joan; Trusolino, Livio; Villanueva, Alberto; the EurOPDX Consortium, for

doi:10.1158/2159-8290.cd-14-0001

Public

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Published in Cancer Discovery • Sep 1, 2014

NobleIDark:/48914/w1/20260526/CA17B49CRecord on NobleID

Authors:

Manuel Hidalgo

,

Frederic Amant

,

Andrew V. Biankin

Abstract

Abstract Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. ...

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