Genomic and Expression Profiling of Human Spermatocytic Seminomas: Primary Spermatocyte as Tumorigenic Precursor and <i>DMRT1</i> as Candidate Chromosome 9 Gene

H. J. Looijenga, Leendert; Hersmus, Remko; Gillis, Ad; Pfundt, Rolph; Stoop, Hans; J. H. L. M. van Gurp, Ruud; A. Veltman, Joris; Berna Beverloo, H.; van Drunen, Ellen; Geurts van Kessel, Ad; A. Reijo Pera, Renee; T. Schneider, Dominik; Summersgill, Brenda; Shipley, Janet; McIntyre, Alan; J. van der Spek, Peter; Schoenmakers, Eric; Wolter Oosterhuis, J.

doi:10.1158/0008-5472.can-05-2936

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Genomic and Expression Profiling of Human Spermatocytic Seminomas: Primary Spermatocyte as Tumorigenic Precursor and DMRT1 as Candidate Chromosome 9 Gene

Published in Cancer Research • Jan 1, 2006

Authors:

Leendert H. J. Looijenga

Remko Hersmus

Ad Gillis

Abstract

Spermatocytic seminomas are solid tumors found solely in the testis of predominantly elderly individuals. We investigated these tumors using a genome-wide analysis for structural and numerical chromosomal changes through conventional karyotyping, spectral karyotyping, and array comparative genomic h...

Subject

Biology

Comparative genomic hybridization

Gene expression profiling

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