Decreasing TNF-alpha results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis.

K, Chen; Y, Wei; GC, Sharp; H, Braley-Mullen

doi:10.1189/jlb.0606402

Public

Decreasing TNF-alpha results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis.

Shared by NobleBlocks on Oct 17, 2006 • 12:00 AM UTC

Authors:

Chen K

Wei Y

Sharp GC

Abstract

Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced in DBA/1 mice by adoptive transfer of mouse thyroglobulin (MTg)-primed spleen cells. TNF-alpha is an important proinflammatory cytokine and apoptotic molecule involved in many autoimmune diseases. To study its role in G-EAT, anti-T...

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