Decreasing TNF-α results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis

Chen, Kemin; Wei, Yongzhong; C. Sharp, Gordon; Braley‐Mullen, Helen

doi:10.1189/jlb.0606402

Public

Decreasing TNF-α results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis

Published in Journal of Leukocyte Biology • Oct 17, 2006

Authors:

Kemin Chen

Yongzhong Wei

Gordon C. Sharp

Abstract

Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced in DBA/1 mice by adoptive transfer of mouse thyroglobulin (MTg)-primed spleen cells. TNF-alpha is an important proinflammatory cytokine and apoptotic molecule involved in many autoimmune diseases. To study its role in G-EAT, anti-T...

Subject

Proinflammatory cytokine

Autoimmune thyroiditis

Tumor necrosis factor alpha

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