Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study

M. Taylor, Steve; M. Parobek, Christian; K. DeConti, Derrick; Kayentao, Kassoum; Oumar Coulibaly, Sheick; Greenwood, Brian; Tagbor, Harry; T. Williams, John; Bojang, Kalifa; Njie, Fanta; Desai, Meghna; Kariuki, Simon; Gutman, Julie; P. Mathanga, Don; Mårtensson, Andreas; Ngasala, Billy; D. Conrad, Melissa; J. Rosenthal, Philip; Tshefu, Antoinette; M. Moormann, Ann; Vulule, John; K. Doumbo, Ogobara; O. ter Kuile, Feiko; R. Meshnick, Steven; A. Bailey, Jeffrey; J. Juliano, Jonathan

doi:10.1093/infdis/jiu467

Public

Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study

Published in The Journal of Infectious Diseases • Sep 1, 2014

Authors:

Steve M. Taylor

Christian M. Parobek

Derrick K. DeConti

Abstract

Plasmodium falciparum parasites that are resistant to artemisinins have been detected in Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13-propeller gene. The molecular epidemiology of these artemisinin resistance genotypes in African parasite populations is u...

Subject

Artemisinin

Plasmodium falciparum

Biology

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