Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

Murtaza, Muhammed; Dawson, Sarah‐Jane; Pogrebniak, Katherine; M. Rueda, Oscar; Provenzano, Elena; W. Grant, John; Chin, Suet‐Feung; W.Y. Tsui, Dana; Marass, Francesco; Gale, Davina; Raza Ali, H.; Shah, Pankti; Contente‐Cuomo, Tania; Farahani, Hossein; Shumansky, Karey; Kingsbury, Zoya; Humphray, Sean; Bentley, David; P. Shah, Sohrab; Wallis, Matthew; Rosenfeld, Nitzan; Caldas, Carlos

doi:10.1038/ncomms9760

Public

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

Published in Nature Communications • Nov 4, 2015

Authors:

Muhammed Murtaza

Sarah‐Jane Dawson

Katherine Pogrebniak

Abstract

Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ER-positive and HER2-positive breast cancer receiving two lines of targeted...

Subject

Somatic evolution in cancer

Metastatic breast cancer

Breast cancer

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