Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

F. Silva, Diana; Eva Selfridge, J.; Lu, Jianghua; S.E, Legge; Roy, Nilanjan; Hutfles, Lewis; M. Burns, Jeffrey; K. Michaelis, Elias; Yan, Shushan; M. Cardoso, Sandra; H. Swerdlow, Russell

doi:10.1093/hmg/ddt247

Public

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

Published in Human Molecular Genetics • Jun 4, 2013

Authors:

Diana F. Silva

J. Eva Selfridge

Jianghua Lu

Abstract

Bioenergetic dysfunction occurs in Alzheimer's disease (AD) and mild cognitive impairment (MCI), a clinical syndrome that frequently precedes symptomatic AD. In this study, we modeled AD and MCI bioenergetic dysfunction by transferring mitochondria from MCI, AD and control subject platelets to mtDNA...

Subject

Bioenergetics

Biology

Mitochondrion

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