DNA Double-Strand Break Repair Genes and Oxidative Damage in Brain Metastasis of Breast Cancer

Woditschka, Stephan; M. Evans, Lynda; Duchnowska, Renata; Tiffany Reed, L.; Palmieri, Diane; Qian, Yongzhen; Badve, Sunil; W. Sledge, George; Gril, Brunilde; I. Aladjem, Mirit; Fu, Haiqing; Flores, Natasha; Gökmen‐Polar, Yesim; Biernat, Wojciech; Szutowicz-Zielińska, Ewa; Mandat, Tomasz; Trojanowski, Tomasz; Och, Waldemar; Czartoryska-Arłukowicz, Bogumiła; Jassem, Jacek; B. Mitchell, James; S. Steeg, Patricia

doi:10.1093/jnci/dju145

Public

DNA Double-Strand Break Repair Genes and Oxidative Damage in Brain Metastasis of Breast Cancer

Published in JNCI Journal of the National Cancer Institute • Jun 1, 2014

Authors:

Stephan Woditschka

Lynda M. Evans

Renata Duchnowska

Abstract

BACKGROUND: Breast cancer frequently metastasizes to the brain, colonizing a neuro-inflammatory microenvironment. The molecular pathways facilitating this colonization remain poorly understood. METHODS: Expression profiling of 23 matched sets of human resected brain metastases and primary breast tum...

Subject

Cancer research

DNA damage

Brain metastasis

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