cAMP/PKA pathway activation in human mesenchymal stem cells <i>in vitro</i> results in robust bone formation <i>in vivo</i>

Siddappa, Ramakrishnaiah; C. Martens, Anton; Doorn, J.; Leusink, Anouk; Olivo, Cristina; Licht, Ruud; van Rijn, Linda; Gaspar, Cláudia; Fodde, Riccardo; W. Janssen, Frank; van Blitterswijk, Clemens; de Boer, Jan

doi:10.1073/pnas.0711190105

Public

cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo

Published in Proceedings of the National Academy of Sciences • May 19, 2008

Authors:

Ramakrishnaiah Siddappa

Anton C. Martens

J. Doorn

Abstract

Tissue engineering of large bone defects is approached through implantation of autologous osteogenic cells, generally referred to as multipotent stromal cells or mesenchymal stem cells (MSCs). Animal-derived MSCs successfully bridge large bone defects, but models for ectopic bone formation as well a...

Subject

Mesenchymal stem cell

Cell biology

In vivo

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!