Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

A. Seder, Robert; Chang, Lee-Jah; E. Enama, Mary; L. Zephir, Kathryn; Sarwar, Uzma; J. Gordon, Ingelise; A. Holman, LaSonji; R. James, Eric; F. Billingsley, Peter; Gunasekera, Anusha; Richman, Adam; Chakravarty, Sumana; Manoj, Anita; Murugan, Vel; Li, MingLin; J. Ruben, Adam; Tao, Li; G. Eappen, Abraham; E. Stafford, R.; H. Plummer, Sarah; S. Hendel, Cynthia; Novik, Laura; Costner, Pamela; Mendoza, Floreliz; Saunders, Jamie; Nason, Martha; H. Richardson, Jason; Murphy, Jittawadee; A. Davidson, Silas; L. Richie, Thomas; Sedegah, Martha; Sutamihardja, Awalludin; A. Fahle, Gary; E. Lyke, Kirsten; B. Laurens, Matthew; Roederer, Mario; Tewari, Kavita; E. Epstein, Judith; Kim Lee Sim, B.; E. Ledgerwood, Julie; S. Graham, Barney; L. Hoffman, Stephen; VRC 312 Study Team, the; DiGiovanni, Cassandra; Williams, Pernell; Luongo, Nicole; Mitchell, Jillian; Burgos Florez, Maria; Larkin, Brenda; M. Berkowitz, Nina; Wilson, Brandon; Clarke, Tanya; Vasilenko, Olga; V. Yamshchikov, Galina; Sitar, Sandra; Stanford, LaChonne; Pittman, Iris; T. Bailer, Robert; P. Casazza, Joseph; DeCederfelt, Hope; Starling, Judith; C. Williams, Esther; F. Lau, Anna; Antonara, Stella; Brocious, Jeffery; A. Kemp, Margaret; Inglese, James; Dranchak, Patricia; Abot, Esteban; Reyes, Sharina; Ganeshan, Harini; Belmonte, María; Huang, Jun; Belmonte, Arnel; Komisar, Jack; Abebe, Yonas; Getachew, Yeab; Patil, Asha; Matheny, Steve; E. Nelson, K.; Overby, James; Pich, Virak; Wen, Yingda; Fan, Richard; Fomumbod, Enni; Awe, Aderonke; Chakiath, Chinnamma; D. King, Mary; Socorro Orozco, Maria; Murshedkar, Tooba; Padilla, Debbie; Jiang, Bing; Gao, Lixin; KC, Natasha; Xu, Rui; Adams, Matthew; V. Plowe, Christopher; Loblein, Hayley; Renehan, Phyllis; Kunchai, Meghan; Diep, Ly

doi:10.1126/science.1241800

Public

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

Published in Science • Aug 9, 2013

Authors:

Robert A. Seder

Lee-Jah Chang

Mary E. Enama

Abstract

Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine--composed of attenuated, aseptic, purified, cryopreserved PfSPZ--was safe and well tolera...

Subject

Malaria

Immunization

Virology

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