Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>

Chen, WanJun; Jin, Wenwen; J. Hardegen, Neil; Lei, Ke-Jian; Li, Li; J. Marinos, Nancy; McGrady, George; M. Wahl, Sharon

doi:10.1084/jem.20030152

Public

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Published in The Journal of Experimental Medicine • Dec 15, 2003

Authors:

WanJun Chen

Wenwen Jin

Neil J. Hardegen

Abstract

CD4+CD25+ regulatory T cells (Treg) are instrumental in the maintenance of immunological tolerance. One critical question is whether Treg can only be generated in the thymus or can differentiate from peripheral CD4+CD25- naive T cells. In this paper, we present novel evidence that conversion of naiv...

Subject

IL-2 receptor

FOXP3

Interleukin 21

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