Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

Barkauskaite, Eva; Brassington, Amy; S. Tan, Edwin; Warwicker, Jim; S. Dunstan, Mark; Banos, Benito; Lafite, Pierre; Ahel, Marijan; J. Mitchison, Timothy; Ahel, Ivan; Leys, David

doi:10.1038/ncomms3164

Public

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

Published in Nature Communications • Aug 6, 2013

Authors:

Eva Barkauskaite

Amy Brassington

Edwin S. Tan

Abstract

Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity generates PAR fragments. Here we present the cr...

Subject

Visualization

Balance (ability)

Chemistry

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