The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

Pasini, Diego; P. Bracken, Adrian; B. Hansen, Jacob; Capillo, Manuela; Helin, Kristian

doi:10.1128/mcb.01432-06

Public

The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

Published in Molecular and Cellular Biology • Mar 6, 2007

Authors:

Diego Pasini

Adrian P. Bracken

Jacob B. Hansen

Abstract

Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation r...

Subject

PRC2

Polycomb-group proteins

Biology

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