Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

Stephens, Len; Anderson, Karen; Stokoe, David; Erdjument-Bromage, Hediye; F. Painter, Gavin; B. Holmes, Andrew; R. J. Gaffney, Piers; B. Reese, Colin; McCormick, Frank; Tempst, Paul; Coadwell, J.; T. Hawkins, Phillip

doi:10.1126/science.279.5351.710

Public

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

Shared by NobleBlocks on Jan 28, 1998 • 12:00 AM UTC

Authors:

Len Stephens

Karen Anderson

David Stokoe

Abstract

Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and PtdIns(3,4)P 2 in the signaling pathways used by a wide variety of growth factors, antigens, and inflammatory stimuli. PKB is a dire...

Discussions