Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

Goede, Valentin; Fischer, Kirsten; Busch, Raymonde; Engelke, Anja; Eichhorst, Barbara; Wendtner, Clemens‐Martin; Chagorova, Tatiana; de la Serna, Javier; Dilhuydy, Marie‐Sarah; Illmer, Thomas; Opat, Stephen; Owen, Carolyn; Samoylova, Olga; Kreuzer, Karl‐Anton; Stilgenbauer, Stephan; Döhner, Hartmut; W. Langerak, Anton; Ritgen, Matthias; Kneba, Michael; Asikanius, Elina; Humphrey, Kathryn; Wenger, Michael; Hallek, Michael

doi:10.1056/nejmoa1313984

Public

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

Published in New England Journal of Medicine • Jan 8, 2014

Authors:

Valentin Goede

Kirsten Fischer

Raymonde Busch

Abstract

BACKGROUND: The monoclonal anti-CD20 antibody rituximab, combined with chemotherapeutic agents, has been shown to prolong overall survival in physically fit patients with previously untreated chronic lymphocytic leukemia (CLL) but not in those with coexisting conditions. We investigated the benefit ...

Subject

Chlorambucil

Obinutuzumab

Medicine

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