Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears

H. Diacon, Andreas; F. Patientia, R.; Venter, Amour; D. van Helden, Paul; J. Smith, Peter; McIlleron, Helen; S. Maritz, J.; R. Donald, Peter

doi:10.1128/aac.01474-06

Public

Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears

Published in Antimicrobial Agents and Chemotherapy • May 22, 2007

Authors:

Andreas H. Diacon

R. F. Patientia

Amour Venter

Abstract

We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rif...

Subject

Sputum

Tuberculosis

Medicine

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