Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

Yan, Huan; Zhong, Guocai; Xu, Guangwei; He, Wenhui; Jing, Zhiyi; Gao, Zhenchao; Huang, Yi; Qi, Yonghe; Peng, Xiaozhong; Wang, Haimin; Fu, Liran; Song, Mei; Chen, Pan; Gao, Wenqing; Ren, Bijie; Sun, Yinyan; Cai, Tao; Feng, Xiaofeng; Sui, Jianhua; Li, Wenhui

doi:10.7554/elife.00049

Public

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

Published in eLife • Nov 13, 2012

Authors:

Huan Yan

Guocai Zhong

Guangwei Xu

Abstract

Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more severe disease. Cellular entry of both viruses is mediated by HBV envelope proteins. The pre-S1 domain of the large envel...

Subject

Virology

Hepatitis B virus

Receptor

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