The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies

Farci, Patrizia; Shimoda, Atsushi; Coiana, Alessandra; Diaz, Giacomo; Peddis, Giovanna; C. Melpolder, Jacqueline; Strazzera, Antonello; Y. Chien, David; J. Muñoz, Santiago; Balestrieri, A; H. Purcell, Robert; J. Alter, Harvey

doi:10.1126/science.288.5464.339

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The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies

Published in Science • Apr 14, 2000

Authors:

Patrizia Farci

Atsushi Shimoda

Alessandra Coiana

Abstract

The mechanisms by which hepatitis C virus (HCV) induces chronic infection in the vast majority of infected individuals are unknown. Sequences within the HCV E1 and E2 envelope genes were analyzed during the acute phase of hepatitis C in 12 patients with different clinical outcomes. Acute resolving h...

Subject

Viral quasispecies

Hypervariable region

Seroconversion

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