Contribution of Hepatic Cytochrome P450 3A4 Metabolic Activity to the Phenomenon of Clopidogrel Resistance

C. Lau, Wei; A. Gurbel, Paul; B. Watkins, Paul; J. Neer, Charlene; S. Hopp, Amy; G.M. Carville, David; E. Guyer, Kirk; R. Tait, Alan; Bates, Eric

doi:10.1161/01.cir.0000112378.09325.f9

Public

Contribution of Hepatic Cytochrome P450 3A4 Metabolic Activity to the Phenomenon of Clopidogrel Resistance

Published in Circulation • Jan 6, 2004

Authors:

Wei C. Lau

Paul A. Gurbel

Paul B. Watkins

Abstract

BACKGROUND: Interindividual variability of platelet inhibition after aspirin or clopidogrel administration has been described. Additionally, aspirin resistance and clopidogrel resistance occur in some individuals. Because the prodrug clopidogrel is activated by hepatic cytochrome P450 (CYP) 3A4, we ...

Subject

Clopidogrel

Medicine

CYP2C19

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