Pharmacokinetics-Pharmacodynamics of Rifampin in an Aerosol Infection Model of Tuberculosis

Jayaram, Ramesh; Gaonkar, Sheshagiri; Kaur, Parvinder; L. Suresh, B.; N. Mahesh, B.; Jayashree, R.; Nandi, Vrinda; Bharat, Sowmya; Krishan Shandil, Radha; Kantharaj, E.; Balasubramanian, V.

doi:10.1128/aac.47.7.2118-2124.2003

Public

Pharmacokinetics-Pharmacodynamics of Rifampin in an Aerosol Infection Model of Tuberculosis

Published in Antimicrobial Agents and Chemotherapy • Jun 23, 2003

Authors:

Ramesh Jayaram

Sheshagiri Gaonkar

Parvinder Kaur

Abstract

Limited information exists on the pharmacokinetic (PK)-pharmacodynamic (PD) relationships of drugs against Mycobacterium tuberculosis. Our aim was to identify the PK-PD parameter that best describes the efficacy of rifampin on the basis of in vitro and PK properties. Consistent with 83.8% protein bi...

Subject

Pharmacokinetics

Pharmacodynamics

Potency

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!