CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Kitade, Hironori; Sawamoto, Kazuki; Nagashimada, Mayumi; Inoue, Hiroshi; Yamamoto, Yasuhiko; Sai, Yoshimichi; Takamura, Toshinari; Yamamoto, Hiroshi; Miyamoto, Ken‐ichi; N. Ginsberg, Henry; Mukaida, Naofumi; Kaneko, Shuichi; Ota, Tsuguhito

doi:10.2337/db11-1506

Public

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Published in Diabetes • Apr 4, 2012

Authors:

Hironori Kitade

Kazuki Sawamoto

Mayumi Nagashimada

Abstract

C-C motif chemokine receptor (CCR)2 and its ligand, monocyte chemoattractant protein (MCP)-1, are pivotal for adipose tissue macrophage (ATM) recruitment and the development of insulin resistance. However, other chemokine systems also may play a role in these processes. In this study, we investigate...

Subject

Insulin resistance

Adipose tissue

Endocrinology

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