Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

Kerschensteiner, Martin; Gallmeier, Eike; Behrens, Lüder; Vargas Leal, Vivian; Misgeld, Thomas; E. F. Klinkert, Wolfgang; Kolbeck, Roland; Hoppe, Edmund; L Oropeza-Wekerle, R; Bartke, Ilse; Stadelmann, Christine; Lassmann, Hans; Wekerle, Hartmut; Hohlfeld, Reinhard

doi:10.1084/jem.189.5.865

Public

Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

Published in The Journal of Experimental Medicine • Mar 1, 1999

Authors:

Martin Kerschensteiner

Eike Gallmeier

Lüder Behrens

Abstract

Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity during development and after injury. In the nervous system, neurons are considered the major cellular source of BDNF. We demonstrate here that in addition, activated human T cells, B cells, and monocytes ...

Subject

Neurotrophic factors

Neuroprotection

Inflammation

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