Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling.

T, Gumbo; A, Louie; MR, Deziel; LM, Parsons; M, Salfinger; GL, Drusano

doi:10.1086/424849

Public

Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling.

Shared by NobleBlocks on Sep 24, 2004 • 12:00 AM UTC

Authors:

Gumbo T

Louie A

Deziel MR

Abstract

Background Moxifloxacin is a quinolone antimicrobial that has potent activity against Mycobacterium tuberculosis. To optimize moxifloxacin dose and dose regimen, pharmacodynamic antibiotic-exposure targets associated with maximal microbial kill and complete suppression of drug resistance in M. tuber...

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