Linifanib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized Phase III Trial

Cainap, Călin; Qin, Shukui; Huang, Wen‐Tsung; Joo Chung, Ik; Pan, Hongming; Cheng, Ying; Kudo, Masatoshi; Kang, Yoon‐Koo; Chen, Pei‐Jer; Toh, Han-Chong; Gorbunova, Vera; A.L.M. Eskens, Ferry; Qian, Jiang; D. McKee, Mark; L. Ricker, Justin; M. Carlson, Dawn; El-Nowiem, Saied

doi:10.1200/jco.2013.54.3298

Public

Linifanib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized Phase III Trial

Published in Journal of Clinical Oncology • Dec 9, 2014

Authors:

Călin Cainap

Shukui Qin

Wen‐Tsung Huang

Abstract

PURPOSE: This open-label phase III trial evaluated efficacy and tolerability of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC) without prior systemic therapy. PATIENTS AND METHODS: Patients were randomly assigned in a 1:1 ratio to linifanib 17.5 mg once daily or ...

Subject

Medicine

Sorafenib

Hepatocellular carcinoma

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