Disialoganglioside (GD3) Synthase Gene Expression Suppresses Vascular Smooth Muscle Cell Responses via the Inhibition of ERK1/2 Phosphorylation, Cell Cycle Progression, and Matrix Metalloproteinase-9 Expression

Moon, Sung‐Kwon; Kim, Hong‐Man; Lee, Young‐Choon; Kim, Cheorl‐Ho

doi:10.1074/jbc.m313462200

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Disialoganglioside (GD3) Synthase Gene Expression Suppresses Vascular Smooth Muscle Cell Responses via the Inhibition of ERK1/2 Phosphorylation, Cell Cycle Progression, and Matrix Metalloproteinase-9 Expression

Published in Journal of Biological Chemistry • Jun 8, 2004

Authors:

Sung‐Kwon Moon

Hong‐Man Kim

Young‐Choon Lee

Abstract

Sialic acid-containing glycosphingolipids (gangliosides) have been implicated in the regulation of various biological phenomena such as atherosclerosis. Recent report suggests that exogenously supplied disialoganglioside (GD3) serves a dual role in vascular smooth muscle cells (VSMC) proliferation a...

Subject

Vascular smooth muscle

Gene expression

Biology

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