Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

Chang, Mei; Nakagawa, Peggy; Williams, Shirley; R. Schwartz, Michael; L. Imfeld, Karen; S. Buzby, Jeffrey; J. Nugent, Diane

doi:10.1182/blood-2002-05-1475

Public

Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

Published in Blood • Apr 8, 2003

Authors:

Mei Chang

Peggy Nakagawa

Shirley Williams

Abstract

To determine if megakaryocytes are targeted by immune thrombocytopenic purpura (ITP) autoantibodies, as are platelets, we have studied the effects of ITP plasma on in vitro megakaryocytopoiesis. Umbilical cord blood mononuclear cells were incubated in the presence of thrombopoietin and 10% plasma fr...

Subject

Megakaryocytopoiesis

Autoantibody

Platelet

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!