Recurrent Fusion of
                    <i>TMPRSS2</i>
                    and ETS Transcription Factor Genes in Prostate Cancer

A. Tomlins, Scott; R. Rhodes, Daniel; Perner, Sven; M. Dhanasekaran, Saravana; Mehra, Rohit; Sun, Xiao-Wei; Varambally, Sooryanarayana; Cao, Xuhong; Tchinda, Joelle; Kuefer, Rainer; Lee, Charles; E. Montie, James; B. Shah, Rajal; J. Pienta, Kenneth; A. Rubin, Mark; M. Chinnaiyan, Arul

doi:10.1126/science.1117679

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Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer

Shared by NobleBlocks on Oct 28, 2005 • 12:00 AM UTC

Authors:

Scott A. Tomlins

Daniel R. Rhodes

Sven Perner

Abstract

Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1 , were identified as outliers in ...

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