A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial–mesenchymal transition

Beltrán, Manuel; Puig, Isabel; Peña, Cristina; Miguel García, José; Belén Cid Álvarez, Ana; Peña, Raúl; Bonilla, Félix; Garcı́a de Herreros, Antonio

doi:10.1101/gad.455708

Public

A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial–mesenchymal transition

Published in Genes & Development • Mar 15, 2008

Authors:

Manuel Beltrán

Isabel Puig

Cristina Peña

Abstract

Expression of Snail1 in epithelial cells triggers an epithelial-mesenchymal transition (EMT). Here, we demonstrate that the synthesis of Zeb2, a transcriptional repressor of E-cadherin, is up-regulated after Snail1-induced EMT. Snail1 does not affect the synthesis of Zeb2 mRNA, but prevents the proc...

Subject

Biology

Intron

Untranslated region

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