Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Ghoreschi, Kamran; I. Jesson, Michael; Xiong, Li; L. Lee, Jamie; Ghosh, Sarbani; W. Alsup, Jason; D. Warner, James; Tanaka, Masao; Steward-Tharp, Scott; Gadina, Massimo; J. Thomas, Craig; C. Minnerly, John; Storer, Chad; P. LaBranche, Timothy; A. Radi, Zaher; E. Dowty, Martin; D. Head, Richard; M. Meyer, Debra; Kishore, Nandini; J. O’Shea, John

doi:10.4049/jimmunol.1003668

Public

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Published in The Journal of Immunology • Mar 8, 2011

Authors:

Kamran Ghoreschi

Michael I. Jesson

Li Xiong

Abstract

Inhibitors of the JAK family of nonreceptor tyrosine kinases have demonstrated clinical efficacy in rheumatoid arthritis and other inflammatory disorders; however, the precise mechanisms by which JAK inhibition improves inflammatory immune responses remain unclear. In this study, we examined the mod...

Subject

Tofacitinib

STAT1

Innate immune system

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