IFN-γ- and TNF-Independent Vitamin D-Inducible Human Suppression of Mycobacteria: The Role of Cathelicidin LL-37

R. Martineau, Adrian; A. Wilkinson, Katalin; M. Newton, Sandra; Andrés Floto, R.; W. Norman, Anthony; Skolimowska, Keira; N. Davidson, Robert; E. Sørensen, Ole; Kampmann, Beate; Griffiths, Chris; J. Wilkinson, Robert

doi:10.4049/jimmunol.178.11.7190

Public

IFN-γ- and TNF-Independent Vitamin D-Inducible Human Suppression of Mycobacteria: The Role of Cathelicidin LL-37

Published in The Journal of Immunology • Jun 1, 2007

Authors:

Adrian R. Martineau

Katalin A. Wilkinson

Sandra M. Newton

Abstract

Vitamin D deficiency is associated with susceptibility to tuberculosis, and its biologically active metabolite, 1alpha,25 dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), has pleiotropic immune effects. The mechanisms by which 1alpha,25(OH)(2)D(3) protects against tuberculosis are incompletely understo...

Subject

Cathelicidin

Calcitriol receptor

Vitamin D and neurology

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