Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

J, Chapuis; F, Hansmannel; M, Gistelinck; A, Mounier; Cauwenberghe C, Van; KV, Kolen; F, Geller; Y, Sottejeau; D, Harold; P, Dourlen; B, Grenier-Boley; Y, Kamatani; B, Delepine; F, Demiautte; D, Zelenika; N, Zommer; M, Hamdane; C, Bellenguez; JF, Dartigues; JJ, Hauw; F, Letronne; AM, Ayral; K, Sleegers; A, Schellens; LV, Broeck; S, Engelborghs; Deyn PP, De; R, Vandenberghe; M, O'Donovan; M, Owen; J, Epelbaum; M, Mercken; E, Karran; M, Bantscheff; G, Drewes; G, Joberty; D, Campion; JN, Octave; C, Berr; M, Lathrop; P, Callaerts; D, Mann; J, Williams; L, Buée; I, Dewachter; Broeckhoven C, Van; P, Amouyel; D, Moechars; B, Dermaut; JC, Lambert

doi:10.1038/mp.2013.1

Public

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

Shared by NobleBlocks on Feb 12, 2013 • 12:00 AM UTC

Authors:

Chapuis J

Hansmannel F

Gistelinck M

Abstract

Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE. We report that BIN1 transcript levels were increased in AD brains and identified a novel 3 bp insertion allele ∼28 kb upst...

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