Large-scale replication and heterogeneity in Parkinson disease genetic loci

Sharma, Manu; P. A. Ioannidis, John; Aasly, Jan; Annesi, Grazia; Brice, Alexis; Van Broeckhoven, Christine; Bertram, Lars; Bozi, Maria; Crosiers, David; E Clarke, Carl; Facheris, Maurizio; J. Farrer, Matthew; Garraux, Gaëtan; Gispert, Suzana; Auburger, Georg; Vilariño‐Güell, Carles; M. Hadjigeorgiou, Georgios; A. Hicks, Andrew; Hattori, Nobutaka; S. Jeon, Beom; Lesage, Suzanne; M. Lill, Christina; Lin, Juei-Jueng; Lynch, Timothy; Lichtner, Peter; E. Lang, Anthony; Mok, Vincent; Jasińska‐Myga, Barbara; D. Mellick, George; Morrison, Karen; Opala, Grzegorz; P. Pramstaller, Peter; Pichler, Irene; Sup Park, Sung; Quattrone, Aldo; Rogaeva, Ekaterina; A. Ross, Owen; Stefanis, Leonidas; Stockton, Joanne; Satake, Wataru; A. Silburn, Peter; Theuns, Jessie; Tan, Eng-King; Toda, Tatsushi; Tomiyama, Hiroyuki; J. Uitti, Ryan; Wirdefeldt, Karin; K. Wszołek, Zbigniew; Xiromerisiou, Georgia; Yueh, Kuo-Chu; Zhao, Yi; Gasser, Thomas; M. Maraganore, Demetrius; Krüger, Rejko; Boyle, R.S; Sellbach, A; D. O’Sullivan, John; T. Sutherland, Greg; Siebert, G.; Dissanayaka, N.; Van Broeckhoven, Christine; Theuns, Jessie; Crosiers, David; Pickut, Barbara; Engelborghs, Sebastiaan; Meeus, Bram; Paul De Deyn, Peter; Cras, Patrick; Rogaeva, Ekaterina; E. Lang, Anthony; Agid, Yves; Anheim, Mathieu; Bonnet, A-M; Borg, Michael; Brice, Alexis; Broussolle, E.; Corvol, Jean‐Christophe; Damier, Philippe; Destée, A.; Dürr, Alexandra; Durif, F.; Lesage, Suzanne; Lohmann, Ebba; Pollak, Pierre; Rascol, Olivier; Tison, François; Tranchant, Christine; Viallet, François; Vidailhet, Marie; Tzourio, Christophe; Amouyel, Philippe; Loriot, Marie‐Anne; Mutez, Eugénie; Duflot, Aurélie; Legendre, Jean-Philippe; Waucquier, Nawal; Gasser, Thomas; Rieß, Olaf; Berg, Daniela; Schulte, Claudia; Klein, Christine; Djarmati, Ana; Hagenah, Johann; Lohmann, Katja; Auburger, Georg; Hilker, Rüdiger; van de Loo, Simone; Dardiotis, Efthimios; Tsimourtou, Vaïa; Ralli, Styliani; Kountra, Persa; Patramani, Gianna; Vogiatzi, Cristina; Hattori, Nobutaka; Tomiyama, Hiroyuki; Funayama, Manabu; Yoshino, Hiroyo; Li, Yuanzhe; Imamichi, Yoko; Toda, Tatsushi; Satake, Wataru; Lynch, Timothy; Mark Gibson, J.; Maria Valente, Enza; Ferraris, Alessandro; Dallapiccola, Bruno; Ialongo, Tàmara; Brighina, Laura; Corradi, B.; Piolti, Roberto; Tarantino, Patrizia; Annesi, Ferdinanda; S. Jeon, Beom; Sup Park, Sung; Aasly, Jan; Opala, Grzegorz; Jasińska‐Myga, Barbara; Kłodowska-Duda, Gabriela; Boczarska‐Jedynak, Magdalena; King Tan, Eng; Carmine Belin, Andrea; Olson, Lars; Galter, Dagmar; Westerlund, Marie; Sydow, Olof; Nilsson, Christer; Puschmann, Andreas; Lin, J-J; M. Maraganore, Demetrius; Ahlskog J, Eric; de Andrade, Mariza; G. Lesnick, Timothy; A. Rocca, Walter; Checkoway, Harvey; A. Ross, Owen; K. Wszołek, Zbigniew; J. Uitti, Ryan

doi:10.1212/wnl.0b013e318264e353

Public

Large-scale replication and heterogeneity in Parkinson disease genetic loci

Published in Neurology • Jul 12, 2012

Authors:

Manu Sharma

John P. A. Ioannidis

Jan Aasly

Abstract

OBJECTIVE: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown. MET...

Subject

Single-nucleotide polymorphism

Genetics

Biology

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