Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.

Gramont A, de; A, Figer; M, Seymour; M, Homerin; A, Hmissi; J, Cassidy; C, Boni; H, Cortes-Funes; A, Cervantes; G, Freyer; D, Papamichael; Bail N, Le; C, Louvet; D, Hendler; Braud F, de; C, Wilson; F, Morvan; A, Bonetti

doi:10.1200/jco.2000.18.16.2938

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Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.

Shared by NobleBlocks on Aug 1, 2000 • 12:00 AM UTC

Authors:

de Gramont A

Figer A

Seymour M

Abstract

Purpose In a previous study of treatment for advanced colorectal cancer, the LV5FU2 regimen, comprising leucovorin (LV) plus bolus and infusional fluorouracil (5FU) every 2 weeks, was superior to the standard North Central Cancer Treatment Group/Mayo Clinic 5-day bolus 5FU/LV regimen. This phase III...

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