Sildenafil citrate therapy for pulmonary arterial hypertension.
Published in The New England journal of medicine • Nov 17, 2005
Authors:,,
Nazzareno Galiè
Hossein A Ghofrani
Adam Torbicki
Abstract
BACKGROUND: Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung. METHODS: In this double-bl...
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