Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension

Galiè, Nazzareno; Ardeschir Ghofrani, Hossein; Torbicki, Adam; J. Barst, Robyn; J. Rubin, Lewis; B. Badesch, David; R. Fleming, Thomas; Parpia, Tamiza; Burgess, Gary; Branzi, Angelo; Grimminger, Friedrich; Kurzyna, Marcin; Simonneau, Gérald

doi:10.1056/nejmoa050010

Public

Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension

Published in New England Journal of Medicine • Nov 16, 2005

Authors:

Nazzareno Galiè

Hossein Ardeschir Ghofrani

Adam Torbicki

Abstract

BACKGROUND: Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung. METHODS: In this double-bl...

Subject

Sildenafil

Cyclic guanosine monophosphate

Medicine

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