Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.

JD, Sandy; J, Westling; RD, Kenagy; ML, Iruela-Arispe; C, Verscharen; JC, Rodriguez-Mazaneque; DR, Zimmermann; JM, Lemire; JW, Fischer; TN, Wight; AW, Clowes

doi:10.1074/jbc.m009737200

Public

Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.

Shared by NobleBlocks on Jan 26, 2001 • 12:00 AM UTC

Authors:

Sandy JD

Westling J

Kenagy RD

Abstract

Mature human aorta contains a 70-kDa versican fragment, which reacts with a neoepitope antiserum to the C-terminal peptide sequence DPEAAE. This protein therefore appears to represent the G1 domain of versican V1 (G1-DPEAAE(441)), which has been generated in vivo by proteolytic cleavage at the Glu(4...

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