Efficacy and Safety of Histrelin Subdermal Implant in Children with Central Precocious Puberty: A Multicenter Trial

A. Eugster, Erica; L. Clarke, William; B. Kletter, Gad; A. Lee, Peter; Kirk Neely, E.; O. Reiter, Edward; Saenger, Paul; I. Shulman, Dorothy; A. Silverman, Lawrence; Flood, Lisa; A. Gray, William; M. Tierney, David

doi:10.1210/jc.2006-2479

Public

Efficacy and Safety of Histrelin Subdermal Implant in Children with Central Precocious Puberty: A Multicenter Trial

Published in The Journal of Clinical Endocrinology & Metabolism • Feb 27, 2007

Authors:

Erica A. Eugster

William L. Clarke

Gad B. Kletter

Abstract

CONTEXT: GnRH analog (GnRHa) therapy for central precocious puberty (CPP) typically involves im injections. The histrelin implant is a new treatment that provides a continuous slow release of the GnRHa histrelin. OBJECTIVE: The objective of the study was to investigate the safety and efficacy of the...

Subject

Medicine

Implant

Adverse effect

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