Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12

Lee, Kyeong‐Sook; Kim, Hyun‐Jung; Li, Qinglin; Chi, Xin‐Zi; Ueta, Chisato; Komori, Toshihisa; M. Wozney, John; Kim, Eung‐Gook; Choi, Je-Young; Ryoo, Hyun‐Mo; Bae, Suk‐Chul

doi:10.1128/mcb.20.23.8783-8792.2000

Public

Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12

Published in Molecular and Cellular Biology • Dec 1, 2000

Authors:

Kyeong‐Sook Lee

Hyun‐Jung Kim

Qinglin Li

Abstract

When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth factor beta1 (TGF-beta1), terminal differentiation into myotubes is blocked. Treatment with bone morphogenetic protein 2 (BMP-2) not only blocks myogenic differentiation of C2C12 cells but also induces osteoblast...

Subject

RUNX2

Biology

Osteoblast

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