New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) – The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations

Matagrin, Benjamin; Hodroge, Ahmed; Montagut-Romans, Adrien; Andru, Julie; Fourel, Isabelle; Besse, Stéphane; Benoît, Etienne; Lattard, Virginie

doi:10.1016/j.fob.2013.02.001

Public

New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) – The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations

Published in FEBS Open Bio • Jan 1, 2013

Authors:

Benjamin Matagrin

Ahmed Hodroge

Adrien Montagut-Romans

Abstract

The systematic use of antivitamin K anticoagulants (AVK) as rodenticides caused the selection of rats resistant to AVKs. The resistance is mainly associated to genetic polymorphisms in the Vkorc1 gene encoding the VKORC1 enzyme responsible for the reduction of vitamin K 2,3-epoxide to vitamin K. Fiv...

Subject

Vitamin

Vitamin K epoxide reductase

Biochemistry

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