Scan statistic-based analysis of exome sequencing data identifies <i>FAN1</i> at 15q13.3 as a susceptibility gene for schizophrenia and autism

Ionita‐Laza, Iuliana; Xu, Bin; Makarov, Vlad; D. Buxbaum, Joseph; L. Roos, Johannes; A. Gogos, Joseph; Karayiorgou, Maria

doi:10.1073/pnas.1309475110

Public

Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism

Published in Proceedings of the National Academy of Sciences • Dec 16, 2013

Authors:

Iuliana Ionita‐Laza

Bin Xu

Vlad Makarov

Abstract

We used a family-based cluster detection approach designed to localize significant rare disease-risk variants clusters within a region of interest to systematically search for schizophrenia (SCZ) susceptibility genes within 49 genomic loci previously implicated by de novo copy number variants. Using...

Subject

Genetics

Biology

Exome sequencing

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