Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis

Eksteen, Bertus; J. Grant, Allister; Miles, Alice; M. Curbishley, Stuart; F. Lalor, Patricia; G. Hübscher, Stefan; Briskin, Michael; Salmon, Mike; Adams, David

doi:10.1084/jem.20041035

Public

Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis

Published in The Journal of Experimental Medicine • Nov 22, 2004

Authors:

Bertus Eksteen

Allister J. Grant

Alice Miles

Abstract

Primary sclerosing cholangitis (PSC), a chronic inflammatory liver disease characterized by progressive bile duct destruction, develops as an extra-intestinal complication of inflammatory bowel disease (IBD) (Chapman, R.W. 1991. Gut. 32:1433-1435). However, the liver and bowel inflammation are rarel...

Subject

Addressin

Primary sclerosing cholangitis

Inflammatory bowel disease

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