Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis.

Y, Tang; V, Katuri; R, Srinivasan; F, Fogt; R, Redman; G, Anand; A, Said; T, Fishbein; M, Zasloff; EP, Reddy; B, Mishra; L, Mishra

doi:10.1158/0008-5472.can-04-4585

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Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis.

Shared by NobleBlocks on May 1, 2005 • 12:00 AM UTC

Authors:

Tang Y

Katuri V

Srinivasan R

Abstract

Although transforming growth factor-beta (TGF-beta) is both a suppressor and promoter of tumorigenesis, its contribution to early tumor suppression and staging remains largely unknown. In search of the mechanism of early tumor suppression, we identified the adaptor protein ELF, a beta-spectrin from ...

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