Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

Tenesa, Albert; M. Farrington, Susan; Prendergast, James; Porteous, Mary; Walker, Marion; Haq, Naila; A. Barnetson, Rebecca; Τheodoratou, Evropi; Cetnarskyj, Roseanne; Cartwright, Nicola; A. Semple, Colin; J. Clark, Andrew; Jane Reid, Fiona; Smith, Lorna; Kavoussanakis, Kostas; Koessler, Thibaud; D.P. Pharoah, Paul; Buch, Stephan; Schafmayer, Clemens; Tepel, Jürgen; Schreiber, Stefan; Völzke, Henry; Oliver Schmidt, Carsten; Hampe, Jochen; Chang‐Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Wilkening, Stefan; Canzian, Federico; Capellá, Gabriel; Moreno, Vı́ctor; J. Deary, Ian; M. Starr, John; Tomlinson, Ian; Kemp, Zoe; Howarth, Kimberley; G. Carvajal‐Carmona, Luis; L. Webb, Emily; Broderick, Peter; Vijayakrishnan, Jayaram; S. Houlston, Richard; Rennert, Gad; G. Ballinger, Dennis; S. Rozek, Laura; B. Gruber, Stephen; Matsuda, Koichi; Kidokoro, Tomohide; Nakamura, Yusuke; W. Zanke, Brent; M.T. Greenwood, Celia; Rangrej, Jagadish; Kustra, Rafal; Montpetit, Alexandre; J. Hudson, Thomas; Gallinger, Steven; Campbell, Harry; G. Dunlop, Malcolm

doi:10.1038/ng.133

Public

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

Published in Nature Genetics • Mar 30, 2008

Authors:

Albert Tenesa

Susan M. Farrington

James Prendergast

Abstract

In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We the...

Subject

Biology

Locus (genetics)

Genome-wide association study

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