The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers

W. Schnider, Thomas; F. Minto, Charles; L. Gambús, Pedro; Andresen, Corina; Goodale, David; L. Shafer, Steven; Youngs, Elizabeth

doi:10.1097/00000542-199805000-00006

Public

The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers

Published in Anesthesiology • May 1, 1998

Authors:

Thomas W. Schnider

Charles F. Minto

Pedro L. Gambús

Abstract

BACKGROUND: Unresolved issues with propofol include whether the pharmacokinetics are linear with dose, are influenced by method of administration (bolus vs. infusion), or are influenced by age. Recently, a new formulation of propofol emulsion, containing disodium edetate (EDTA), was introduced in th...

Subject

Propofol

Pharmacokinetics

Volunteer

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