5-Aminoimidazole-4-Carboxamide-1-β-<scp>d</scp>-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase–Independent Effect on Glucokinase Translocation

Guigas, Bruno; Bertrand, Luc; Taleux, Nellie; Foretz, Marc; Wiernsperger, Nicolas; Vertommen, Didier; Andréelli, Fabrizio; Viollet, Benoı̂t; Hue, Louis

doi:10.2337/diabetes.55.04.06.db05-1178

Public

5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase–Independent Effect on Glucokinase Translocation

Published in Diabetes • Apr 1, 2006

Authors:

Bruno Guigas

Luc Bertrand

Nellie Taleux

Abstract

AMP-activated protein kinase (AMPK) controls glucose uptake and glycolysis in muscle. Little is known about its role in liver glucose uptake, which is controlled by glucokinase. We report here that 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), metformin, and oligomycin activated AM...

Subject

AMPK

Glucokinase

AMP-activated protein kinase

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