A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

Nicholson, George; Rantalainen, Mattias; V. Li, Jia; D. Maher, Anthony; Malmodin, Daniel; R. Ahmadi, Kourosh; H. Faber, Johan; Barrett, Amy; L. Min, Josine; W. Rayner, Nigel; Toft, Henrik; Krestyaninova, Maria; Vīksna, Juris; Guha Neogi, Sudeshna; Dumas, Marc‐Emmanuel; Sarkans, Uğis; Donnelly, Peter; Illig, Thomas; Adamski, Jerzy; Suhre, Karsten; Allen, Maxine; T. Zondervan, Krina; D. Spector, Tim; K. Nicholson, Jeremy; C. Lindon, John; Baunsgaard, Dorrit; Holmes, Elaine; I. McCarthy, Mark; Holmes, Chris

doi:10.1371/journal.pgen.1002270

Public

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

Published in PLoS Genetics • Sep 8, 2011

Authors:

George Nicholson

Mattias Rantalainen

Jia V. Li

Abstract

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of indi...

Subject

Biology

Single-nucleotide polymorphism

Genetics

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!