The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

Fallarino, Francesca; Grohmann, Ursula; You, Sylvaine; C. McGrath, Barbara; R. Cavener, Douglas; Vacca, Carmine; Orabona, Ciriana; Bianchi, Roberta; Laura Belladonna, Maria; Volpi, Claudia; Santamaría, Pere; C. Fioretti, Maria; Puccetti, Paolo

doi:10.4049/jimmunol.176.11.6752

Public

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

Published in The Journal of Immunology • Jun 1, 2006

Authors:

Francesca Fallarino

Ursula Grohmann

Sylvaine You

Abstract

Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that the short-term, combined effects of tryptophan deprivation and tryptophan catabolites resul...

Subject

IL-2 receptor

Catabolism

Effector

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