Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

Huang, Wei; M. Booth, David; C. Cane, Matthew; Chvanov, Michael; A. Javed, Muhammad; L. Elliott, Victoria; A. Armstrong, J.; Dingsdale, Hayley; Cash, Nicole; Li, Yan; Greenhalf, William; Mukherjee, Rajarshi; S. Kaphalia, Bhupendra; Jaffar, Mohammed; H. Petersen, Ole; V. Tepikin, Alexei; Sutton, Robert; N. Criddle, David

doi:10.1136/gutjnl-2012-304058

Public

Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

Published in Gut • Oct 25, 2013

Authors:

Wei Huang

David M. Booth

Matthew C. Cane

Abstract

OBJECTIVE: Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters (FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial injury and acute pancreatitis (AP). This study investigated the relative importance of oxidative and non-oxidative pathway...

Subject

Ethanol

ATP synthase

Ethyl ester

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