Overactivated neddylation pathway as a therapeutic target in lung cancer.

Li, Lihui; Wang, Mingsong; Yu, Guangyang; Chen, Ping; Li, Hui; Wei, Dongping; Zhu, Ji; Xie, Li; Jia, Huixun; Shi, Jieyi; Li, Chunjie; Yao, Wantong; Wang, Yanchun; Gao, Qiang; Shin Jeong, Lak; Woo Lee, Hyuk; Yu, Jinha; Hu, Fengqing; Mei, Ju; Wang, Ping; Chu, Yiwei; Qi, Hui; Yang, Meng; Dong, Ziming; Sun, Yi; M Hoffman, Robert; Jia, Lijun

doi:10.1093/jnci/dju083

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Overactivated neddylation pathway as a therapeutic target in lung cancer.

Shared by NobleBlocks on Jun 1, 2014 • 12:00 AM UTC

Authors:

Lihui Li

Mingsong Wang

Guangyang Yu

Abstract

BACKGROUND: A number of oncoproteins and tumor suppressors are known to be neddylated, but whether the neddylation pathway is entirely activated in human cancer remains unexplored. METHODS: NEDD8-activating enzyme (NAE) (E1) and NEDD8-conjugating enzyme (E2) expression and global-protein neddylation...

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